Actors, artists, broadcasters and musicians
- Christina Aguilera — singer and songwriter
- Charles Bronson — actor
- John Buccigross — host, Sportscenter on ESPN
- Theodore Crawford "Ted" Cassidy — actor, best known as Lurch on The Addams Family
- Perry Como — pop music singer
- Chip Ganassi — NASCAR and Indycar Team Owner
- Jeff Goldblum — actor
- Charles Grodin — actor
- Holly Hunter — actress
- Jesse Joyce — comedian seen on Comedy Central
- Michael Keaton — actor
- Gene Kelly — dancer, actor, singer, director, and choreographer
- Henrietta Leaver — Miss America 1935
- Oscar Levant — pianist, talk show host
- Rush Limbaugh — Disk jockey at KQV, on-air name "Jeff Christie"
- Henry Mancini — musician and composer
- The Marcels — 60's doo-wop group best known for their #1 hit "Blue Moon"
- Dean Martin — actor, pop music singer
- Dennis Miller — Comedian
- Demi Moore — actress
- David Newell — actor, best known as "Mr. McFeely" on Mr. Rogers' Neighborhood
- Zachary Quinto — actor, Heroes (TV series)
- Fred Rogers — "Mister Rogers"; famous American children's entertainer. Of course Mr. Rogers' Neighborhood was also filmed in Pittsburgh
- George Romero — director, best known for Night of the Living Dead
- Ian Rosenberger — reality show contestant on Survivor: Palau
- Justin Sane — lead guitarist and co-singer/songwriter of the political punk rock band Anti-Flag
- David O. Selznick — film producer, Gone With The Wind (among other films)
- Gertrude Stein — writer, poet, playwright, and feminist
- Jimmy Stewart — actor and Air Force officer
- Tamara Tunie — actress best known as "Dr. Melinda Warner" on Law and Order: SVU
- Andy Warhol — artist
- August Wilson — playwright
Athletes
- Ken Griffey, Jr. — Outfielder 1989-present
- Ken Griffey, Sr. — Outfielder 1973-1991, World Series
- Bill Mazeroski — Only player ever to decide a World Series by a 7th game Home Run
- Honus Wagner — Hall of Fame member
- Michael Moorer — Heavyweight Champion of the World 1992-1993, 1994, 1996-1999
- LaVar Arrington — Linebacker 2000-2006- Went to North Hills High School!
- Bill Cowher — head coach 1992-2007, two Super Bowls
- Mike Ditka — tight end (1961-1972) and coach (1982-1999), three Super Bowls
- Tony Dorsett — Heisman Trophy winner (1976) and running back 1977-1988, two Super Bowls
- Dan Marino — quarterback 1983-1999, Hall of Fame, Super Bowl
- Joe Montana — quarterback 1979-1994, Hall of Fame, four Super Bowls, three Super Bowl MVPs
- Joe Namath — quarterback 1965-1977, Hall of Fame, Super Bowl MVP.
- Lynn Swann — Wide Receiver 1974-1982, Hall of Fame, four Super Bowls, Super Bowl MVP
- Arnold Palmer
- Kurt Angle — 1996 Olympic gold medalist in freestyle wrestling and current professional wrestler for Total Nonstop Action Wrestling
Business and industry
- Eric F. Buell — founder and chairman Buell Motorcycle Company
- Andrew Carnegie — Steel tycoon and philanthropist, founded what became U.S. Steel
- Henry Clay Frick — Steel tycoon, Chief operation officer of what became U.S. Steel
- Charles Martin Hall — Aluminum producer and founder of Alcoa
- Henry J. Heinz — Founder of H J Heinz Company
- Samuel Martin Kier — father of the American Oil Industry
- E. W. Marland — Oilman founded what would become Conoco Oil and also became the governor of Oklahoma
- Andrew Mellon — served as chairman of Mellon Financial helped to found Westinghouse, Alcoa, Gulf Oil and General Motors, became the longest serving United States Secretary of the Treasury in both years and administrations.
- Paul O'Neill — Alcoa CEO and United States Secretary of the Treasury
- Richard Mellon Scaife — runs descendants of Mellon fortune, has published the Pittsburgh Tribune-Review since 1969.
- George Westinghouse — Engineer and inventor
Culture
- William D. Boyce — Founder, Boy Scouts of America
- Rachel Carson — author and ecologist
- David McCullough — historian and author
- Donald Wuerl — eleventh Bishop of the Roman Catholic Diocese of Pittsburgh, current Archbishop Archdiocese of Washington
- Admiral Robert Peary — the first person to reach the North Pole
Educators, scientists, and researchers
- Jonas Salk — physician and inventor of first polio vaccine
- Jesse Steinfeld — United States Surgeon General under President Richard Nixon
Politicians and governmental leaders
- Robert Bork — United States Supreme Court nominee, and acting United States Attorney General in the 1970s.
- James J. Davis — Secretary of Labor under Presidents Harding, Coolidge, and Hoover
- Harmar Denny — United States Congressman from Pennsylvania from 1825 to 1837.
- Mike Doyle — United States Congressman serving Pennsylvania
- Orrin Hatch — United States senator for Utah from 1977 to present.
- John Heinz — United States senator for Pennsylvania and United States Representative 1971-1977.
- Philander C. Knox — United States senator for Pennsylvania 1901-1904 and 1917-1921, United States Attorney General 1901-1904, and United States Secretary of State 1909-1913
- Janet Napolitano — Arizona Governor
- Ron Paul — United States Congressman serving Texas, and 2008 presidential election candidate.
- Tom Ridge — governor of Pennsylvania 1995-2001 and the first Secretary of Homeland Security under George W. Bush
- Rick Santorum — United States senator for Pennsylvania from 1995-2007
- Dick Thornburgh — governor of Pennsylvania 1979-1987 and United States Attorney General for Ronald Reagan and George H.W. Bush.
- Tom Vilsack — governor of Iowa from 1999 to 2007, Secretary of Agriculture-Designate
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